Abstract. REIS JR., J.L.; SILVA, F.L.; RACHID, M.A. and NOGUEIRA, R.H.G.. Renal amyloidosis in a Shar-Pei dog: A case report. Arq. Bras. Med. Vet. Zootec. Imagem da capa: A amiloidose ocorre frequentemente em indivíduos de meia- idade ou . crônicas ou de diálise renal de longo prazo. A maioria dos casos. Bakris GL, Williams M, Dworkin L, et al: Preserving renal function in adults Am J Kidney Dis , sentarão amiloidose na biópsia renal(1).

Author: Mikajas Vogore
Country: Gambia
Language: English (Spanish)
Genre: Software
Published (Last): 15 December 2009
Pages: 158
PDF File Size: 10.89 Mb
ePub File Size: 7.6 Mb
ISBN: 671-2-87018-780-3
Downloads: 66740
Price: Free* [*Free Regsitration Required]
Uploader: Nijind

The absence of amyloid type classification led the Nephrology department of CHSJ to start a systematic classification of all cases of amyloid nephropathy by immunohistochemistry. It is more associated with female gender, amiloidkse age and comorbidities such as hypertension, diabetes, obesity and chronic kidney disease.

Relevant Facts

However, genetic factors may also be involved on this namely SAA genotype Six patients had unequivocal hereditary amyloidosis. Diagnosis for amyloid diseases needs histological confirmation Advances in cardio imaging methods combined with the possibility of performing genetic tests and identification of the type of amyloid material allow the diagnosis to be made.

Services on Demand Journal. ATTR amyloidosis was identified only in two cases, what was expected since this study was performed outside the referral centre for the disease in northern Portugal. In addition, this is the first case in which a renal biopsy showed the concomitant diagnosis of TB granulomas and AA amyloidosis deposits. Obici L, Merlini G. In cases in which DNA sequencing detects a mutant amyloid precursor, protein analysis is the definitive evidence 9.

GluVal e TTR p.

| BJN Brazilian Journal of Nephrology (Jornal Brasileiro de Nefrologia)

Swiss Med Wkly ; N Eng J Med ; 6: Amyloid ; 19 Suppl1: Merlini G, Bellotti V. Source s of support in the form of grants, equipment, drugs, or all of these This work was supported by a grant from the Portuguese Society of Nephrology and by the Multidisciplinary Unit for Biomedical Research that is funded by grants from the Foundation for Science and Technology FcompFEDER Besides the long period of our study, the prevalence of AA amiloidoze remained stable from to Fig.


Patients and Data Collection A total of consecutive patients with different types of amyloidoses were included. The amyloidosis type according to immunohistochemical amyloid protein identification was AA in 60 Amyloid ; 17 The clinical features at kidney biopsy are listed in Table II.

Patients with AA amyloidosis should first and foremost be treated for the underlying inflammation. N Eng J Amilokdose ; The ALys patient had rheumatoid arthritis. Renal transplantation in systemic amyloidosis-importance of amyloid fibril type and precursor protein abundance. Porto University Medical Dissertation ; Systemic amyloidosis in England: Health care resources for this disease Expert centres Diagnostic tests Patient organisations 11 Orphan drug s How to cite this article.

Commonly, paraffin-embedded tissue is used for the typing of amyloid by immunohistochemistry. Fevers, genes, and innate immunity. Nevertheless, our findings agree with results of other series: A amyloidosis was the amiloidoose frequent form of systemic amyloidosis in our series, similarly to what was reported in the largest series of renal amyloidosis in kidney biopsies described by Panizo The mean age at time of kidney biopsy for the entire group was Rfnal those patients, only the first diagnostic biopsy was analysed.

AA amyloidosis, in our series, affected younger individuals, which may be related to early beginning of most of the underlying conditions, mainly infectious and inflammatory diseases, and therapeutic failures at suppressing inflammation. But, among us, chronic infectious disorders are still the most frequent cause of AA amyloidosis, mainly pulmonary tuberculosis, which is according to the fact that Portugal rwnal has one of the highest tuberculosis incidence rates in European Union countries Virchows Arch Pathol Anat Physiol ; 6: Amyloid ; 11 1: Probably due to treatment, Ziehl-Neelsen stains were negative.


Specialised Social Services Eurordis directory. Our four AFib patients were from the same region and had the same amyloidogenic mutation, so haplotyping studies are necessary to conclude if they belong rdnal the same family.

The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis amilodiose diagnosis or treatment. Although they have been known since the time of Virchow, in the 19th century 4,5until recently amyloidoses were considered a medical curiosity with only academic interest rather than clinically relevant diseases.

Our patient had cystic fibrosis since age 5 and AA amyloidosis was diagnosed at 21 years old. Chest radiography showed amioidose opacification in the upper lobe of the left lung, but laboratory tests were negative for tuberculosis TB. Pathogenesis, diagnosis and treatment of systemic amyloidosis. Amyloidosis; diagnosis; hereditary; immunohistochemistry;kidney. However, it has limitations, mainly related with the low sensitivity of the technique, spectrum of amyloid antibody panel, low quality of the analysed tissue and observer experience 15, Am J Kidney Dis ; 56 6: ATTR was identified in two 2.

Mainly affected amiloudose the kidneys, heart, GI tract, liver, skin, peripheral amiloiose and eyes, but any organ can be affected. Two years later, the albumin level was 4.