1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.
|Published (Last):||17 April 2015|
|PDF File Size:||5.18 Mb|
|ePub File Size:||10.73 Mb|
|Price:||Free* [*Free Regsitration Required]|
No cases of transmission of viral diseases or CJD have ever been identified for albumin. Hemolytic-uremic syndrome, thrombotic thrombocytopenic purpura TTP.
Patients should be closely monitored for signs of hepatic avojex and caution exercised when interferon beta-1a is concomitantly with other drugs associated with hepatic injury e. Hepatic injury including elevated hepatic enzymes, jaundice, and hepatitis, some of which have been severe, has been reported in patients receiving interferon beta-1a see Adverse Reactions. As compared with inser from patients who got late treatment, patients who received interferon beta-1a initially had lower expanded disability status scale progression, relapse rate, and T2 disease burden up to 8 years later; the benefit was greater with the higher interferon beta-1a dose.
Interferons and efavirenz can both cause hepatotoxicity. Safety lock is released when blue rectangle area above the oval medication display window is gone.
We’re strengthening digital security to protect you.
Your doctor will recommend an injection site suitable for you. Interferon beta has antiviral activity against herpes virus, human avobex, hepatitis B, hepatitis C, and human immunodeficiency syndrome virus. Check the display window and make sure the Avonex is clear and colorless. Interferon beta-1a acts similarly to native interferon beta. Reduce the risk of relapse. It does not contain all the available information.
It should be colourless or slightly pacakge. Titrate patients to the full dose over a 4-week period packagr the Rebif titration pack, which contains 6 doses of 8. Interferon beta-1a-induced hematologic toxicity is dose related. Do not hold the Pen cover with your hands while inserting the needle. Interferon beta inhibits the expression of pro-inflammatory cytokines including INF-G, which is believed to be a major factor responsible for triggering the autoimmune reaction leading to multiple sclerosis.
Interferon beta binds to the type 1 interferon receptor with greater affinity than interferon insertt. It is important that a qualified health care professional supervises your first injection. Moderate Use together with caution and monitor for hepatic decompensation.
Cover exposed needle with Pen cover. Interferon beta has also been found to increase avonwx of nerve growth factor NGFwhich promotes oligodendrocyte survival and differentiation and axonal recovery. After being taught to self-inject, you should refer to the leaflet in the pack for step-by-step instructions about how to prepare and inject AVONEX.
Immediately discontinue Rebif if jaundice or other symptoms of liver dysfunction appear. Sometimes they are serious, most of the time they are not. If you are not sure whether you should use this medicine, talk to your doctor or pharmacist. Send the page ” ” to a friend, relative, colleague or yourself. The circular display window on the Pen will be yellow if you have received the full dose. The above list includes very serious side effects.
Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Avonex (interferon beta-1a) dose, indications, adverse effects, interactions from
Delay the onset of definite MS after an illness suggesting MS. Used to treat depression. When the injector shield is extended the right way, there will be a small blue rectangular area next to the oval medication display window. If the goal dose is 44 mcg, in weeks 1 to 2 administer 8. The effects of interferon beta-1a during labor and delivery are unknown.
Allergic reactions, including anaphylaxis have been reported with interferon beta-1a use. This allows the temperature of the medicine to approach room temperature.
Autoimmune disease of multiple target organs has been reported during interferon beta-1a therapy, including idiopathic thrombocytopenia, thyroid disease hyperthyroidism or hypothyroidismand rare cases of autoimmune hepatitis. All patients got either of the 2 interferon beta-1a doses for the next 4 years; patients who had originally received placebo were randomized to one of the 2 interferon beta-1a dose groups late treatment group.
If you are commencing therapy on Powder for injection, you should speak to your doctor or MS nurse as to how to gradually increase your dose.