Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el. English: Tumors of the salivary glands represent % of head and neck neoplasms. Mucoepidermoid carcinoma (MEC) is the most common epithelial.

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The follow-up period in this study ranged from 6 to months median 65 monthsand the 5 and year OS rates were both Selecting antibodies to detect HER2 overexpression by immunohistochemistry in invasive mammary carcinomas.

Mucoepidermoid carcinoma of the salivary glands clinical review of 42 cases. Head Neck, 26 4: Expression of c-erbB-2 oncoprotein carcihoma salivary gland tumours: The Kaplan-Meier method was used to plot survival curves with the log rank test for analysis of cumulative survival rates.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

Review of the literature and clinicopathological analysis of 18 patients. The high percentage of previously observed positive cases 21 cases, Surgical resection was performed in all patients. Histologically, the tumors were classified as low, intermediate and high grade, according to Auclair et al. The broad age range observed in saliva,es series supports that reported in literature. Microscopically, 27 cases However, there are few articles with a significative number of cases Lopes et al.


Additionally, a significant influence on prognosis was observed in DFS curves depending on the primary anatomical site. Salivary gland tumors in children and adolescents: Oral Oncol, 41 1: Cytoplasmic expression was also observed cwrcinoma not considered in this study as reported in diverse salivary gland tumors Kernohan et al.

The use of skim milk as an economical and effective substitute for commercial biotin solutions. Microscopically, most intraoral MEC were classified as low grade of maligancy 27cases – High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. The majority of MECs 27 cases were classified as low grade of malignancy. R; Dempsey, R J.

This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. Even though low-grade tumors did not develop metastases and high-grade tumors showed lower DFS rates after five years, no significant difference was found for the grading system or any of the evaluated carcinom factors.

Carcinoma mucoepidermoide

Mucoepidermoid carcinoma of the salivary glands -clinical review of 42 mucoepidermoidde. The 5 and year overall survival rates were both Although MEC has been described as a radioresistant tumor, postoperative radiotherapy has been associated with decreased recurrence in some reports.

Complementary studies to compare carbohydrates of the normal salivary glands must be carried out because subtle alterations in tumor cells glycosylation can influence their biological behavior. The clinicopathologic features and results of log rank tests for clinical variables are mucoepider,oide in tables 1 and 2respectively.


Clinicopathologic and immunohistochemical study of intraoral mucoepidermoid carcinoma. The follow-up period in this study ranged from 6 to months. Mucoepidermoid carcinoma of the salivary glands in Brazil: Growth Factors, 24 2: Thus, our findings may suggest the lack of association among clinicopathological features and the immunoexpression of c-erbB Evaluation of the immunohistochemical staining.

Carcinoma mucoepidermoide

Mucoepidermoid carcinoma MEC is the most common malignant neoplasm of major and minor salivary glands Lopes et al, Intraoral mucoepidermoid carcinoma of salivary glands. HER2 expression in salivary gland carcinomas: Mucoepidermoid carcinoma of minor salivary glands: Although this current investigation was limited by a relatively small sample size, there was a long follow-up period in which we could verify and confirm the influence of some prognostic factors.

MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, Although the significance of this cytoplasmic staining remains unknown, Cheng et al.

The c-erbB-2 oncoprotein is involved in matrix degradation and proteolitic activity as well as in the increase in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation Verbeek et al.