The authors document the cytological features on fine-needle aspiration cytology of a chondroblastoma which appeared as a lytic lesion in the. Chondroblastoma is an uncommon benign cartilage producing neoplasm with a characteristic epiphyseal location. This report documents the. Chondroblastoma is a rare primary bone tumor of young people .. Fine needle aspiration cytology of chondroblastoma of bone. Cancer.
|Published (Last):||10 April 2010|
|PDF File Size:||20.95 Mb|
|ePub File Size:||1.66 Mb|
|Price:||Free* [*Free Regsitration Required]|
Case Report: Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist
Churchill Livingstone Elsevier, No mitotic figures were seen. Page views in Cytologg, multiple aspirations from different sites and awareness of the associations are important. Their anatomic and theoretical basis with an emphasis on radiology, pathology and clinical biology.
Eur J Med Res. Skeletal Radiol ; The nuclei of the chondroblasts are round-to-ovoid, sometimes bean-shaped, and nuclear folding often causes nuclear grooves to be identified. Long-term clinical follow-up is mandated because of high risk of recurrence and chobdroblastoma occurence of malignant transformation.
Plain X-ray showed a well-defined osteolytic lesion involving the right upper fibular epiphysis with a sclerotic rim figure 1.
Various investigations like routine blood and urine examination, serum acid and alkaline phosphatase, serum calcium and phosphorus were within normal limits. An year-old-female presented with pain in left leg for last 1-month and progressively increasing swelling around the knee joint for last 15 days.
On cytology, chondroblastoma is a cell-rich tumor in contrast to matrix-rich CMF.
Resembles tissue culture chpndroblastoma cartilage cells with prominent fibrous lamina that causes microscopic well defined cell borders. A clinico-pathological study of sixty-nine cases. Ultrastructure of cartilaginous tumors and S protein in the tumors. Fine needle aspiration cytology provides a simple, quick, easy and reliable method of preoperative diagnosis of chondroblastoma and can be used as a substitute of chondroblaxtoma biopsy. None, Conflict of Interest: The multinucleated giant cells are a constant cytological feature of smears from chondroblastoma.
Discovered on gastrointestinal stromal tumour 1 DOG1: National Center for Biotechnology InformationU. A case chondroblqstoma and review of literature. Chondromyxoid fibroma closely mimics chondroblastoma due to the presence of myxoid background substance, chondroid fragments and chhondroblastoma giant cells; however, its spindle-shaped or stellate, fibroblast-like tumour cells in contrast to the mononuclear cells of chondroblastoma with distinct cell borders, round-to-oval nuclei and dense eosinophilic cytoplasm help in differentiating these two entities.
Conclusion Chondroblastoma is a rare bone tumor, the cytomorphology of which is very characteristic. Sternberg’s Diagnostic Surgical Pathology.
Cytological diagnosis of chondroblastoma: diagnostic challenge for the cytopathologist
However, it is unclear whether malignant CMF actually exists or whether it represents another type of sarcoma that has been misdiagnosed. Presence of chondroid matrix is believed to be the decisive feature chondroblastkma differentiate cytloogy from giant cell tumor, which is seen better in Giemsa-stained smears than in Papanicolaou-stained smears.
A Reinterpretation of the so-called calcifying or chondromatous giant cell tumor. Chondroblastoma was first described by Codman inwho designated it as “epiphyseal chondromatous giant cell tumor”. Bone Cartilaginous tumors other than chondrosarcoma Chondroblastoma Author: Patella, pelvis, fibula, small bones of hands and feet, ribs, skull, mandible, maxillae, vertebrae, scapulae and sternum are considered as atypical localizations.
In addition to this, the presence of chicken wire calcification is a useful clue to the accurate diagnosis of chondroblastoma at FNAC. There was no history of trauma. Schajowicz F, Gallardo H. One had swelling at the lower end of the femur, whereas in the other case the upper end of the tibia was involved.
Other methods such as curettage alone, endoscopic curettage, endoscopic curettage chondrobllastoma cementation, curettage with fat implantation, resection with allograft replacement, marginal resection radiofrequency ablation and osteochondral autograft transfer have also been used with some success. Kilpatrick SE, Romeo S. Conclusion Fine needle aspiration cytology provides a simple, quick, easy and reliable method of preoperative diagnosis of chondroblastoma and can be used as a substitute of surgical biopsy.
Cytology smears in both the cases showed similar findings.
There was no recurrence observed on 2-year follow-up of the case. The individually lying chondroblasts are typically round mononuclear cells with distinct cell borders and rounded, lobulated or reniform nuclei with longitudinal nuclear grooves, delicate nuclear chromatin and dense glassy cytoplasm. Areas of increased cell density forming fibrous cap were noted at the periphery of lobules. Clinical diagnosis was giant cell tumor of bone.
The chondroblasts were distributed singly in smears, had round to oval nuclei with indentation and lobulation, and fine evenly distributed chromatin. Atlas of tumor pathology, second series, fascicle 5. Fine needle aspiration cytology of chondroblastoma and chondromyxoid fibroma: Arch Putti Chir Organi Mov ; J Foot Ankle Surg.
Smears characteristically revealed chondroblasts and osteoclast-like giant cells.
Pathology Outlines – Chondroblastoma
A report of 2 cases. Presence of chondroid matrix is believed to be the decisive feature to differentiate chondroblastoma from giant cell tumor, which is seen better in Giemsa-stained smears than in Papanicolaou-stained smears. The histological diagnosis of typical chondroblastoma is not chondroblawtoma due to their characteristic appearance with rounded or polygonal chondroblasts, multinucleated giant cells and eosinophilic chondroid extracellular matrix with focal chicken-wire calcification.
Flecks of gritty, calcific material may be observed.