Diagnosis of Endometrial Biopsies and Curettings by Michael Mazur, , available at Book Depository with free delivery. Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach. Veli Marjoniemi. x. Veli Marjoniemi. Search for articles by this author. Department of. Generally, this should comprise a formal curetting rather than an outpatient biopsy. An external Diagnostic algorithm for examination of endometrial biopsies.

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J Clin Pathol 58 1—6.

The menopausal status as well as the date of onset of the last menstrual period and the length of the menstrual cycle in premenopausal women should be provided.

Am J Surg Pathol 24 — The management of adenofibroma and adenosarcoma is identical, comprising hysterectomy. With considerable glandular crowding, however, a diagnosis of complex hyperplasia should be made.

Bridging between adjacent glands, resulting in a cribriform pattern, as well as the presence of luminal necrosis with polymorph infiltration, suggests an adenocarcinoma. Description Derived from the authors’ long-running course presented at the International Academy of Pathology, this second edition, now with color illustrations, continues the tradition of its predecessor as being the concise and complete diagnostic guide to the endometrial biopsy. Goodreads is the world’s largest site for readers with over 50 million reviews.

Diagnosis of Endometrial Biopsies and Curettings : Michael Mazur :

As women with breast cancer are more likely to develop endometrial carcinoma due to common risk factors, such as high socioeconomic status, low parity or hyperoestrogenic states, it is difficult to ascertain whether a true association exists between tamoxifen and the development of endometrial cancer. Looking for beautiful books? Biopsy pathology of the endometrium.


In Curetfings, however, the smooth muscle stroma is generally more cellular and disorganised than normal myometrium. Tearing of the tissue is seen around the glands. Plasma cells may be present in the stroma of endometrial polyps and also in association with an endometrial malignancy.

In diagnosjs review, I will outline my approach to the interpretation of endometrial biopsy specimens, especially concentrating on areas which, in my experience, create difficulties for pathologists. Diagnosis of endometrial biopsies and curettings. Endometrial stromal cells may have a plasmacytoid appearance with eccentric nuclei, and the pathologist should be certain that classic plasma cells are present. Don’t have an account?

EIN terminology has been extensively championed by Mutter and coworkers. Obviously, if a cancer is identified in an endometrial polyp removed by biopsy, it is impossible to ascertain, without full evaluation of the surrounding endometrium, whether the cancer has arisen in or has secondarily involved the polyp.

Diagnosis of Endometrial Biopsies and Curettings : A Practical Approach

Effects of tamoxifen on the endometrium Tamoxifen is widely used as buopsies therapy in the management of breast cancer. In complex hyperplasia, there is an increase in the gland to stroma ratio with glandular crowding.

Int J Gynecol Pathol 15 — Cytoplasmic changes, including increased cytoplasmic eosinophilia, may also be seen in various endometrial metaplasias, such as ciliated metaplasia. Malignant neoplasms of the uterine corpus in patients treated for breast carcinoma: The endometrial glands are positive but the stroma is negative.

A diagnosis biopsiex a papillary adenocarcinoma should not be made without specification of the biopsles type. Please review our privacy policy. Other tissues that may be present in an endometrial biopsy specimen include myometrial smooth muscle and tissue derived from the lower uterine segment or isthmus.

Associated cytological atypia is usually mild or moderate. In a small percentage of cases without these features, there is vaginal recurrence after hysterectomy. The following points on endometrial polyps are worthy of mention:.


Mucinous proliferations of the endometrium, which are identified on biopsy, can be subdivided into categories based on the degree of architectural complexity, which correspond to an increasing risk of the presence of mucinous adenocarcinoma in subsequent hysterectomy. The effects of tamoxifen on the endometrium has been the subject of several reviews. Oxford University Press is a department of the University of Oxford.

Briefly, five criteria must be fulfilled for a diagnosis of EIN: The pathological diagnosis is generally straightforward if the gynaecologist is aware of the presence of a polyp, has conveyed this information to the pathologist and has removed the polyp intact.

Hum Pathol 29 — Endometrial hyperplasia In my experience, lf aspects related to endometrial hyperplasia commonly create problems for pathologists. This is not biopsis, as these two lesions are part of a spectrum without clearly defined boundaries. Previously, wnd biopsy specimens were largely obtained by dilatation and curettage carried out under general anaesthesia. Often, the gynaecologist is not aware of the presence of a polyp.

Purchase Subscription prices and ordering Short-term Access To purchase short term endometriao, please sign in to your Oxford Academic account above. It is emphasised that in the absence of the other morphological features of endometritis described earlier, an exhaustive search for plasma cells is not justified.

Tavassoli FA, Devilee P, eds. Mixed epithelial and mesenchymal tumours.

Feeley K M, Wells M.