La polineuropatía desmielinizante inflamatoria crónica es un trastorno neurológico caracterizado por debilidad progresiva y función sensorial alterada en las. Disease definition. Subacute inflammatory demyelinating polyneuropathy (SIDP) is a subacute progressive symmetric sensorial and/or motor disorder. Disease definition. Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a.

Author: Akinosida Yoramar
Country: Panama
Language: English (Spanish)
Genre: Video
Published (Last): 7 July 2004
Pages: 392
PDF File Size: 6.93 Mb
ePub File Size: 2.88 Mb
ISBN: 826-2-61965-735-9
Downloads: 96552
Price: Free* [*Free Regsitration Required]
Uploader: Mazurg

Orphanet: Neuropatia desmielinizante cr nica com gamapatia IgM monoclonal

Diagnostic methods Diagnosis is based on clinical and electrophysiological findings. However, it is not known whether this association is also part of unspecific immune activation, genetic susceptibility or if it just desmielinizanes by random.

All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. For all other comments, doenaz send your remarks via contact us. Brain magnetic resonance imaging MRI disclosed pons and cerebellum FLAIR and T2 hyperintense signal and mild gadolinium enhancement compatible with demyelination Figurecerebro-spinal fluid was normal.

The authors suggest that the association might be caused by subclinical systemic lupus erythematosus in three of them due to the presence of antinuclear antibodies, including both cases with recurrent DD, although this has been contested due to the fact that two of their patients could actually have NMO Detailed information Article for general public Svenska A clinical diagnosis of neuromyelitis optica was made based on the Wingerchuck criteria 16 and she was started on azathioprine plus prednisone.


Thyroid function and circulating antithyroid antibodies in myasthenia gravis.

Viewing playlist: Doenças metabólicas/dis e desmielinizantes |

Myasthenia gravis accompanied by alopecia areata: Patients with MG can present other autoimmune diseases in association, commonly hypo or hyperthyroidism.

Data from her thymectomy was unavailable from the other hospital. Myasthenia gravis and multiple sclerosis: Neuromyelitis optica associated with myasthenia gravis: Rare cases of spontaneous remission have also been reported. Accepted 10 December Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. The association of MG to demyelinating disease is rare and has been described before. She underwent thymectomy one year later and evolved asymptomatic on pyridostigmine treatment, thymus pathology disclosed lymphoid hyperplasia.

We report on a series of Brazilian patients that presented distinct DD years after the diagnosis of MG.

Additional information Further information on this disease Classification s 1 Gene s 0 Clinical signs and symptoms Other website s 0.

He was initially treated with prednisone and pyridostigmine with mild response to treatment.

Two of our patients have undergone thymectomy and only one presented positive ANA patient 3 ; interestingly, this was the only one that evolved to a recurrent DD.

Desmielinizates disease in patients with myasthenia gravis. Occasionally, CSF studies reveal mild lymphocytic pleocytosis and elevated gamma globulins. The documents contained in this web site are presented for information purposes only. Rarely, cranial nerve dysfunction and respiratory failure may occur.

At age 45 he developed pain, low visual acuity and ptosis in the left eye. Other search option s Alphabetical list. She recently became pregnant and stopped her medication, but her neurological exam discloses only mild low visual acuity without fatigue.


In both series, as in other cases reported before 7, patients developed DD years after undergoing thymectomy, and the authors suggest that thymectomy might have induced immune dysregulation. Subacute inflammatory demyelinating polyradiculoneuropathy Prevalence: Services on Demand Journal. Only doenaa seeking to improve the quality and accuracy of information on the Orphanet website are accepted.

Patient 2 had intermittent diplopia since the age of 27 and was further diagnosed with ocular myasthenia.

Check this box if you wish to receive a copy of your message. Disease definition Polyneuropathy associated with IgM monoclonal gammapathy MG with anti-MAG myelin-associated-glycoprotein activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait.

Doenças metabólicas/dis e desmielinizantes

In this series of patients, only one developed a relapsing-remitting disease with positive low titer ANA and the others presented a monophasic course. On first evaluation she had an atrophic optic disc on the left side, mild spastic gait and increased muscle stretch reflexes. Diagnosis is coenas on clinical and electrophysiological findings.

For all other comments, please send your remarks via contact us.