CASE REPORT. Membranoproliferative associated with type II in a renal transplant patient with hepatitis C. Glomerulonefrite membranoproliferativa em. Disease definition. Dense deposit disease, a histological subtype of MPGN (see this term) is an idiopathic chronic progressive kidney disorder distinguished by. Glomerulonefrite membranoproliferativa. Classificação Até achados estruturais e histopatológico fisiopatologia e.

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Race was significantly associated with histologic type; the odds of being classified as black or mulatto were approximately 2. He was admitted in the hospital for further investigation. Health care resources for this disease Expert centres Diagnostic tests 12 Patient organisations 34 Orphan drug s 4.

Kidney Int ;77 8: An allograft biopsy was performed and showed lesions compatible with MPGN.

Hepatitis C virus antibody status and survival after renal transplantation: Patients from the Renal Service of the Federal University of Bahia, Brazil, 80 with focal segmental glomerulosclerosis FSG and 50 with membranoproliferative glomerulonephritis MPGN were compared regarding the distribution of the racial types black, mulatto, white.

Natural History, Pathogenesis, Membranoptoliferativa and Management.

Orphanet: Glomerulonefrite membranoproliferativa tipo 2

Treatment of this entity is a complex issue, nonconsensual and represents a challenge to clinicians. According to KDIGO clinical practice guidelines oftreatment with interferon should be reserved to patients with fibrosing cholestatic hepatitis or life-threatening vasculitis For these reasons we decided to treat the patient with this drug.


Dense deposit disease, a histological subtype of MPGN see this term is an idiopathic chronic progressive kidney disorder distinguished by the presence of intra-membranous dense deposits in addition to immune complex subendothelial deposits in the glomerular capillary walls.

Antiviral therapy is not routinely recommended in a renal transplant patient because of concerns regarding allograft rejection. Two months after the last dose of rituximab, the SCr improved to 1. The allograft biopsy showed lesions compatible with membranoproliferativewith staining in the immunofluorescence for granular IgM and C3 and no C4d. Membranoproljferativa most common HCV-related nephropathy is membranoproliferative glomerulonephritis MPGNusually in the context of cryoglobulinaemia 6,7.

Foi perdido o follow-up do doente.

Membranoproliferative associated with type II in a renal transplant patient with hepatitis C. Boceprevir for untreated chronic HCV genotype 1 infection. Kidney Int ;69 3: Other glomerular diseases have also been reported, such as membranous nephropathy, minimal change disease, thrombotic microangiopathy, acute transplant glomerulopathy and chronic transplant glomerulopathies 1,4,5.

Os anticorpos antinuclear e anti-double stranded DNA foram negativos.

Kidney Int ;54 2: Cryoglobulinaemia; hepatitis C; kidney transplant; membranoproliferative glomerulonephritis; rituximab. Clin Transplant ;20 6: The patient was lost for follow-up.

Glomerulonefrite membranoproliferativa

Patients with systemic lupus erythematosus or any kind of autoimmune disease were not included in the present analysis. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.


To date, there are no studies glomerulonefirte this therapy in renal transplant and randomized controlled trials are needed In our case, the treatment with rituximab resulted in a favourable outcome, although a longer follow-up period may be needed to evaluate the clinical response, since other studies reported high relapse rates.

N Engl J Med ; The association of this virus with mixed cryoglobulinaemia in our case may be explained by the presence membranoprolifeativa circulating anti-HCV antibodies, and the presence of HCV-RNA in the cryoprecipitate, suggesting that HCV exerted a pathogenic role in the formation of cryoglobulins. Detailed information Professionals Clinical genetics review English Despite the presence of anti-HCV antibodies, the viral load remained undetectable. Como citar este artigo. The documents contained in this web site are presented for information purposes only.

Renal involvement in hepatitis C infection: This diagnostic was surprising since the patient presented with sustained membranoproljferativa viral load, but there are other reported cases in the literature of HCV-related glomerulonephritis in patients with undetectable HCV-RNA Membranoproliferatifa induces regression of hepatitis C virus-related membranoproliferative in a renal allograft.

Chronic hepatitis C virus infection in renal transplant: Hepatitis C virus-associated glomerulonephritis without hepatitis C virus in the blood. InTech, Chapters published February 13,