Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Idiopathic thrombocytopenic purpura (ITP) is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. Eur J Haematol Suppl. Mar;(71) doi: /j x. Immune thrombocytopenic purpura: epidemiology and implications for.

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In one of the small study by Emilia et al [ 6 ], which consisted of 30 subjects, H. The decision to treat ITP is based on the platelet count, degree of bleeding, trombositopenix patient’s lifestyle.

Red Blanchable Erythema Generalized drug eruptions viral exanthems toxic erythema systemic lupus erythematosus. Werlhof, is characterized by premature destruction of autoantibody-coated platelets [ 1 ], causing thrombocytopenia and subsequent mucocutaneous bleeding. Diabetes mellitus type 1 Hashimoto’s thyroiditis Multiple sclerosis Coeliac disease Giant-cell arteritis Postorgasmic illness syndrome Reactive arthritis. The authors declare no conflict of interest or commercial affiliation related to this study.

Chronic immune thrombocytopenia persists longer than six months with a specific cause being unknown. Initial treatment usually consists of the administration of corticosteroidsa group of medications that suppress the immune system.

Patient was admitted in Hematology Ward, Government General Hospital, Chennai on and treatment idiopatki started as described below: However, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines [10] and a normal bleeding time does not exclude a platelet disorder. Pathogenesis of Helicobacter pylori infection.

Several studies have proposed that H. For patient with active H. Nevertheless, in the case of an ITP patient already scheduled for surgery who has a dangerously low platelet count and has experienced a poor response to other treatments, IVIg can rapidly increase platelet counts, and can also help reduce the risk of major bleeding by transiently increasing platelet counts.


Petechia of the lower leg in a person with platelets of 3 due to ITP.

Immune thrombocytopenic purpura: epidemiology and implications for patients.

Other biochemical examinations, liver function tests, and ultrasonography of abdomen were normal. If the disease does not get better with prednisone, other treatments may include: This website also contains material copyrighted by 3rd parties.

Hence one may be considered thrombocytopenic below that range, although the threshold for a diagnosis of ITP is not tied to any specific number. This smear demonstrates the absence of immature leukocytes as in leukemia and fragmented erythrocytes as in thrombotic thrombocytopenic idiopxtik and no clumps of platelets as in pseudothrombocytopenia.

Treatment recommendations sometimes differ for adult and pediatric ITP.

Fetal blood analysis to determine the platelet count is not generally performed as ITP-induced thrombocytopenia in the fetus is generally less severe than NAIT. Infobox medical condition new All trombositopenua lacking reliable references Articles lacking reliable references from July Cellular immune mechanisms in autoimmune thrombocytopenic purpura: Petechiae, or small bruise-like markings, may occur in ITP.

Later withdrawal of wysolone resulted in the relapse steroid dependant thrombocytopenia of another episode of melena. To date, the diagnosis of ITP is still arrived at by tromhositopenia, i.

Long-term responses seen with rituximab in patients with ITP. In chronic refractory cases, where immune pathogenesis has been confirmed, [15] trommbositopenia off-label use of the vinca alkaloid [16] [17] [18] and chemotherapy agent vincristine may be attempted. Recent evidence suggests that the stimulus for autoantibody production in ITP is due to abnormal T helper cells reacting with platelet antigens on the surface of antigen presenting cells.

Immune thrombocytopenic purpura: epidemiology and implications for patients.

In a fifth, the platelet count normalized completely; this response rate is similar to that found in treatment with rituximab, which is more expensive phrpura less safe. N Engl J Med ; Chronic idiopathic thrombocytopenic purpura. The exact mechanism by which dapsone assists in ITP is unclear. An analysis for anti-platelet antibodies is a matter of clinician’s preference, as there is disagreement on whether the 80 percent specificity of this test is sufficient to be clinically useful.


A bone purpkra aspiration or biopsy may also be done. On complete blood cell count, isolated thrombocytopenia is the hallmark of ITP. Bleeding time is prolonged in ITP patients; however, the use of bleeding time in diagnosis is discouraged by the American Society of Hematology practice guidelines as useless. Idiopathic thrombocytopenic purpura ITP is defined as a hematologic disorder, characterized by isolated thrombocytopenia without a clinically apparent cause. Foreign Allergic contact dermatitis Mantoux test.

Platelet transfusion alone is normally not recommended except in an emergency, and is usually unsuccessful in producing a long-term platelet count increase. Transfusion-associated graft versus host disease.

Trombositkpenia mild cases, only careful observation may idiopatlk required but very low counts or significant bleeding may prompt treatment with corticosteroidsintravenous immunoglobulinanti-D immunoglobulinor immunosuppressive medications.

Treatment should be restricted to those patients with moderate or severe thrombocytopenia who are bleeding or at risk of bleeding. The infection by Helicobacter pylori strains expressing CagA is highly prevalent in women with autoimmune thyroid disorders.


The incidence of ITP is estimated at 50— new cases per million per year, with children accounting for half of that amount. No lab test can reliably predict if neonatal thrombocytopenia will occur. Foreign Hemolytic trobositopenia of the newborn. Please review our privacy policy. Splenectomy is sometimes undertaken, as platelets targeted for destruction will often meet their fate in the spleen. Hematoma, idiopathic idoipatik purpura, petechiae, platelets.

Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura.