ANNEX I. SUMMARY OF PRODUCT CHARACTERISTICS. 1 INTEGRILIN is indicated for the prevention of early myocardial infarction in adults presenting. Package leaflet: Information for the patient. Integrilin mg/ml solution for infusion eptifibatide. Read all of this leaflet carefully before you start using this. 1. Package leaflet: Information for the patient. Eptifibatide Accord 2 mg/ml solution for injection eptifibatide. Read all of this leaflet carefully before you start using.
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Dilution Eptifibatide – Integrilin ® – GlobalRPH
Avoid concomitant use 1 4. In patients who received transfusions, the corresponding loss in hemoglobin was estimated through an adaptation of the method of Landefeld et al. Iintegrilin Overall incidence of major bleeding 9.
Determine platelet counts prior to treatment and periodically e. By clicking Subscribe, I agree to the Drugs. Dosage of heparin required to maintain an appropriate activated clotting time ACT during concomitant therapy with eptifibatide may be lower than with heparin monotherapy.
In patients who undergo coronary artery bypass graft surgery, eptifibatide infusion should be discontinued prior to surgery. Not known whether eptifibatide is distributed into breast milk.
In any case, both heparin and Integrilin should be discontinued and sheath hemostasis should integrili achieved at least 2 to 4 hours before hospital discharge.
By clicking Subscribe, I agree to the Drugs. Safety and effectiveness of Eptifibatide Injection in pediatric patients have not been studied. Administration of Eptifibatide Injection is associated with an increase in major and minor bleeding, as classified by the criteria of the Thrombolysis in Myocardial Infarction Study group TIMI [see Adverse Reactions 6. Use contraindicated in patients with hepatic disease severe enough to alter synthesis of coagulation factors.
Integripin Interaction Intrgrilin Anticoagulants, oral Potential increased risk of bleeding 1 Use with caution 1 Dipyridamole Potential increased risk of bleeding 1 Use with caution 1 Enoxaparin Pharmacokinetic or pharmacodynamic e. Plasma elimination half-life is approximately 2. The activated partial thromboplastin time aPTT should be maintained between 50 and 70 seconds unless PCI pwckage to be performed. Print this page Add to My Med List.
Usual Diluents Administer directly from vial. To view content sources and attributions, please refer to our editorial policy.
packgae Available for Android and iOS devices. Most of the serious nonbleeding adverse reactions consisted of cardiovascular reactions typical of a UA population. When obtaining intravenous access, avoid non-compressible sites e.
As shown in Table 7, each Integrilin regimen reduced the rate of death, MI, or urgent intervention, although at 30 days, this finding was statistically significant only in the lower-dose Integrilin group. A total of patients underwent PCI within 72 hours after randomization, in which case they received intravenous heparin to maintain an ACT of to seconds.
The primary endpoint was the composite of death, MI, or urgent revascularization, analyzed at 30 days after randomization in all patients who received at least 1 dose of study drug.
The need for thrombotic “bailout” was significantly reduced with Integrilin at 48 hours 2. In a baboon model that is refractory to aspirin and heparin, doses of eptifibatide that inhibit aggregation prevented acute thrombosis with only a modest prolongation 2- to 3-fold of the bleeding time.
Each vial of packxge size also contains 5. Bleeding was classified iintegrilin major or minor by the criteria of the TIMI study group. Before infusion of Eptifibatide Injection, the following laboratory tests should be performed to identify pre-existing hemostatic abnormalities: Patients were randomly assigned to 1 of 3 treatment regimens, each incorporating a bolus dose initiated immediately prior to PCI followed by a continuous infusion lasting 20 to 24 hours:. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
The mL vial should be spiked with a vented infusion set. Do not use beyond the labeled expiration date. Subscribe to receive email notifications whenever new articles are published. Medically reviewed on Sep 18, As reported by the investigators, the occurrence of death from any cause or new MI for patients followed for at least days was reduced from This infusion dose completely inhibited canine coronary thrombosis induced by coronary artery injury Folts model.
Infusion should continue until hospital discharge or initiation of coronary artery bypass graft surgery CABGup to 72 hours If a patient is to integrikin PCI, the infusion should be continued until hospital discharge or for up to packxge to 24 hours after the procedure, whichever comes first, allowing for up to 96 hours of therapy Aspirin, to mg, should be given daily. These findings suggest acute thrombocytopenia after the administration of Eptifibatide Injection can develop as a result of naturally occurring drug-dependent antibodies or those induced by prior exposure to Eptifibatide Injection.
In both cases, plasma for antibody detection was collected approximately 30 days after each dose.
No incompatibilities observed with IV administration sets; no compatibility studies performed with polyvinyl chloride PVC bags. Differences among ethnic groups have not been assessed.