LIQUISOLID COMPACTS PDF

Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.

Author: Taucage Tetaur
Country: Slovenia
Language: English (Spanish)
Genre: Love
Published (Last): 17 February 2012
Pages: 148
PDF File Size: 15.23 Mb
ePub File Size: 3.25 Mb
ISBN: 882-4-44074-561-9
Downloads: 76341
Price: Free* [*Free Regsitration Required]
Uploader: Fenrik

The less drug concentration in the vehicle means more fraction of the drug is liable to be in the liquid solution form i. This question is for testing whether you are a human visitor and to prevent automated spam submissions.

The aim of present investigation was to prepare liquisolid compacts of high dose water insoluble drug, carbamazepine CBZ using novel porous carriers such as Neusilin and Fujicalin in order to improve its dissolution rate and reduce the tablet weight. Concentration of dissolved drug was determined using standard equation.

Abstract Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally.

As shown in Table 5LSA 15 showed prompt drug release with value of The interaction between liqujsolid and liquksolid was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients. From the dissolution profiles, it can be seen that all liquisolid formulations significantly improved drug dissolution compared to conventional tablets. Liquisolid compacts are acceptably flowing and compressible powder forms of liquid medications.

To this liquid medication, the calculated amount of the carrier was added by continuous mixing in the mortar.

This indicates that there is no interaction between the drug and excipients. Composition of liquids solid compacts batches ccompacts shown in Table 1. All liquisolid preparations were compacted into tablets using a ten-station rotary compression machine Rimek, Karnavati Engineering, India using flat-faced punch with a compression force that provide acceptable tablet hardness.

  ALAIN DE BOTTON ENSAYOS DE AMOR PDF

Clmpacts for more related articles at Journal of Pharmacovigilance. The flowable liquid retention potential was calculated using the following equation: Liquisllid of hydrophobic drugs show very poor dissolution in the gastro intestinal tract, leading to erratic and incomplete drug absorption. Indexed in Web of Science. Moreover, the inclusion of disintegrating agents may further enhance the drug release from this system.

It is a prodrug rapidly deesterified during absorption from the gastrointestinal tract to produce an active metabolite, olmesartan [ 7 ].

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International

IntJ Pharm PharmSci 2: The prepared liquisolid compacts were evaluated and compared for thickness, diameter, weight variation, uniformity of content, hardness, friability, disintegration and in vitro dissolution. The tensile strength of the tablet was also sufficient. The and for liquid vehicles were used to calculate. The liquisolid technology is described by Spireas as liquid may oiquisolid transformed into a free-flowing, readily compressible, and apparently dry powder by simple physical blending with selected excipients named the carrier and coating material Figure 1.

Acrysol EL proved to be promising liquid vehicle for formulation of liquisolid preparations. Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. Liquisolid compacts were prepared using Acrysol El as a solvent, Avicel PHFujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios.

The solubility is an important factor in liquisolid systems, as higher solubility of drug in liquid vehicle can lead to higher dissolution rates since the drug will be more molecularly dispersed and more surface of drug will be exposed to the dissolution media. To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties.

Spireas S Liquisolid systems and methods of preparing same.

  DEVALLIS RUTLEDGE PDF

FTIR spectroscopy helps to determine any chemical interaction between drug and excipients used in formulation. Over past few decades, many techniques have been developed, to improve the solubility and dissolution of poorly soluble substances, with different degrees of success which includes micronization, lyohilization, solid dispersion, etc.

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement

The excipient and coating material are to be taken into definite ratios so as to retain the accepted amount of liquid to be converted into liqkisolid. At higher values the greater amount of carrier may overcome to some extent the flow properties of powder. Then, coating material was carefully added and mixed until mortar contents start to look dry.

A powder may be able to retain only limited amounts of liquid while maintaining acceptable flow and compression properties.

It can be concluded from this study that liquiso,id porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose drugs like CBZ. To calculate the required amounts of powder excipients including both carrier and coating materials a mathematical approach for the formulation of liquisolid systems has been developed by Spireas [ 78 ].

Journal of Drug Delivery

Piquisolid three principal suggested mechanisms include an increased surface area of drug particles, an increased aqueous solubility, and an improved wettability of the drug particles. However, this technique cannot be applied to high dose poorly soluble drugs is because of the high amount of liquid vehicle needed.

Six tablets from each formulation were tested for hardness.

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.