Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment. Lycopene (LYC) is an antioxidant. Background: The exact role of lycopene has not been studied in the past for its hepatoprotective effects. Hence it was decided to explore its anti-oxidant and. In this experimental approach we have established measurements of the hepatoprotective efficiency of lycopene using oxidative stress markers in both.

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The immunoreactive antibodies were visualized by incubation with DAB-H 2 O 2 at room temperature for 10 min.

Low density lipoprotein-cholesterol; HDL-C: The rats in BPA displayed high activities of serum hepatoprotctive enzymes with low levels of total proteins TP and albumin.

Hepatoprotective Effect of Olive and Argan Oils Supplemented with Tomato Lycopene in Wistar Rats

Observed with the naked eye, the livers of the control group were deep red, moist, glossy and resilient Figure 2AIwhile those of the model group showed yellow necrotic foci, grey-red color, loss of luster and tumescent Figure 2AII.

Also, there has been no model exploring the effect of lycopene on BPA exposure; thus, the current study aimed at examining whether LYC has a potential protective action against BPA-induced hepatotoxicity in cyclic female rat model with concern to biochemical, oxidative stress, and antioxidant capacity in the liver tissue as well as histopathological alterations, percent of DNA in comet tail, and hepatic caspase-3 protein contents.

Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced heaptoprotective in rats. Introduction Liver is the major organ in the body responsible for detoxification and metabolism, resulting in the production of free radicals, which are very reactive and unstable [ 1 ].

The occurrence of abnormalities in lipid profile is considered the starting station for induction of oxidative stress and lipid peroxidation [ 58 ] that were observed in the current study. International Journal of Pharma Sciences. These obtained results were concurring with those recorded by Moon et al.


Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

View at Google Scholar J. Hepatoproetctive fatty liver disease NAFLD is one of the causes hepaatoprotective fatty liver, occurring when fat is deposited steatosis in the liver due to causes other than excessive alcohol use.

Ninety percent of patients with NAFLD show close relation with one or more of the following risk factors: NAFLD is defined by hepatic fat deposition in the absence of excessive alcohol intake, which is also associated with the insulin resistance IR and metabolic syndrome[ hepatoprootective – 20 ]. Gong ZM L- Editor: This can obviously illustrate the higher B. In the LYC group, nonsignificant changes occurred compared to the control group Table 4. Histopathological sections of female Wistar rats.

Bisphenol A BPA —an endocrine disruptor xenoestrogen—is widely spread in the environment. A probability level of indicated significance. Table 3 Effect of lycopene on low density lipoprotein-cholesterol, high density lipoprotein-cholesterol hepatoprotextive free fatty acid levels in liver tissue. The variation in results may be attributed to the diversity in diet composition, BPA exposure period, route and doses, and animal strain. On the other hand, some reports in the literatures were inconsistent to our findings, where Rubin et al.

G was calculated by subtracting the initial from the final body weight F. Abdelrazek2 Dalia W. Institutional review board statement: Dietary carotenoids protect human cells from damage.

Our results were in harmony with Morrissey et al. Body and Liver Weights Rats were weighed at the beginning of hepatoprotrctive experiment and then weighed at the end of the experiment. NASH is characterized by hepatocellular damage, fibrogenesis and lobular necro-inflammation[ 2122 ], which may evolve to hepatic cirrhosis and HCC[ 2324 ].


View at Google Scholar W. Moreover, administration of BPA disrupted hepatic integrity and functions where liver is jepatoprotective the main organ involved in plasma protein biosynthesis [ 50 ]; thus, serum TP and albumin were declined.

Moreover, BPA can alter the antioxidant enzymes in different body systems [ 4041 ] as noted in the current study, thus could alter gepatoprotective weight gain of the experimental rats. The effects of lycopene were compared with silymarin. These results could be attributed to the toxic effect of BPA that could encounter several body homeostatic pathways, among which neuronal appetite loop in the brain [ 38 ], where BPA can easily cross blood brain barrier lhcopene have estrogenic effect [ 39 ].

The 1st group received corn oil and considered as a control. A significant decrease was observed in the levels of serum AST 2. Spectrum of clinical lesions.

Table 2 Effect of lycopene on liver antioxidant enzyme-specific activities, antioxidant and lipid peroxidation levels.

In addition, the histopathological changes from microscopy observation correlated with the examination of liver function. Journal of Taibah University for Science. J Inflamm Lond ; All slides were lightly counterstained with hematoxylin hepatoprrotective 30 seconds prior to dehydration and mounting [ 34 ].

A Grade B Lycopfne good: High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia. Rats supplemented with LYC only did not differ from the control group Table 2. View at Google Scholar A. Additionally, it can retrieve the peroxyl radicals, thus restraining lipid peroxidation pathway [ 20 ].