Manitol versus solución salina hipertónica en neuroanestesia It appears that a low dose of mannitol acts as a renal vasodilator while high-dose mannitol is. Randomized, controlled trial on the effect of a 20% mannitol solution and a % saline/6% dextran solution on increased intracranial pressure. Introduction Hyperosmolar therapy with mannitol or hypertonic saline (HTS) is the primary medical management strategy for elevated intracranial pressure (ICP).

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Argument against using hyperosmolar agents in an intracranial pressure-directed manner The use of hyperosmolar agents to reduce an elevated ICP is one of several therapies recommended by the Brain Trauma Foundations guideline on the management of severe TBI. Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries.

Mannitol or hypertonic saline in the setting of traumatic brain injury: What have we learned?

Out of the 17 patients who were randomized in each group, 9 patients received only mannitol, 12 received only sodium lactate, and 13 patients crossed over and received both mannitol and sodium lactate. A prospective, randomized comparison hiperonica pentobarbital and mannitol.

Mannitol-induced acute renal failure. Abel Wakai 15 Estimated H-index: InWeed and McKibben first described the effect of osmotherapy in laboratory animals by showing that hypertonic fluids reduced brain bulk and ICP.

Interstitial oedema results from altered CSF absorption and increased transependymal CSF flow, as is the case in hydrocephalus, for example.

In 11 studies, HTS infusion was used and the majority showed hiperyonica to be effective for ICP control, but only 3 of those studies were prospective and randomized. While several mechanisms contribute to poor outcome, impaired cerebral perfusion appears to be a highly significant common denominator.


Severe trauma activates the inflammatory cascade, inducing the systemic inflammatory response syndrome. Therefore, in the brain, remains in the vascular fluid compartment and eolucion removes the intracellular space and intersticial. It has a low probability of anaphylactic reactions or of transmitting infectious agents, and it easily controlled by serum Na levels.

Brain tumours Cerebral oedema rarely presents in a pure form, and the two types of hipertonicca are found together in many clinical situations, making clinical distinction difficult. La HIC y el edema cerebral suelen ser las consecuencias de lesiones cerebrales agudas y cronicas tales como el trauma craneoencefalico severo, el accidente cerebrovascular isquemico, la hemorragia intracerebral, la hemorragia subaracnoidea aneurismatica, y sv tumores e hipertojica cerebrales.

There are multiple studies that show that HTS – particularly The use of hypertonic saline in the treatment of traumatic brain injury. Equimolar doses of mannitol and hypertonic saline in the treatment of increased intracranial pressure.

The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure. Cochrane Database Syst Rev. This is a prospective, nonrandomized, and cross-over study that compares the effects on brain tissue oxygen tension PbtO 2 of mannitol and HTS. Lazaridis, in a meta-analysis conducted inidentified 11 papers on the use of Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension.

The mean reduction in ICP for mannitol was 7. A potential role in the pathophysiology of vascular changes following traumatic brain injury. Many of the problems have not been elucidated yet, hence the need for additional research in order to arrive at a definitive conclusion about the superiority of these hyperosmolar agents and for protocols with adequate doses and concentrations of these agents as first-line therapy to control intracranial hypertension.


Effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury. Soluclon saline solutions for treatment of intracranial hypertension. Riou B, Carli P.

Mannitol versus hypertonic saline solution in neuroanaesthesia

Compared to mannitol, the effect of sodium lactate solution on ICP was significantly more pronounced 7 vs. The study by Bentsen et al. The benefit solucuon HTS relative to long-term neurological out-comes compared to that of mannitol is yet unclear.

Pharmacokinetics and effects of mannitol on hemodynamics, blood and cerebrospinal fluid electrolytes and osmolality during intracranial surgery. The concept of guiding treatment by Manjtol monitoring was recently challenged in a study by Chesnut et al.

It has been very difficult to assess the efficacy of hypertonic saline solution or compare it with other protocols used for mannitol due to the wide variety of concentrations available and majitol number of protocols employed. To-date, the cornerstone therapy in neurological emergencies with intracranial hypertension is ICP reduction.

Hypertonic sodium chloride and hemorrhagic shock.